- Review Article
- Endocrinology
- Genetic factors in precocious puberty
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Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
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Clin Exp Pediatr. 2022;65(4):172-181. Published online October 18, 2021
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· Mutations in the kisspeptin (KISS1), kisspeptin receptor (KISS1R), makorin ring finger protein 3 (MKRN3), and delta-like homolog 1 (DLK1) genes are associated with idiopathic central precocious puberty (ICPP).
· A few genes related to pubertal onset have been implicated in ICPP.
· Epigenetic factors such as DNA methylation, histone posttranslational modifications, and noncoding ribonucleic acids may be related to ICPP |
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- The genes associated with gonadotropin-releasing hormone-dependent precocious puberty
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Jin Soon Hwang
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Clin Exp Pediatr. 2012;55(1):6-10. Published online January 31, 2012
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Human puberty is a complex, coordinated biological process with multiple levels of regulations. The timing of puberty varies greatly in children and is influenced by both environmental and genetic factors. The key genes of pubertal onset, KISS1, GPR54, GNRH1 and GNRHR, may be major causal factors underlying gonadotropin-releasing hormone-dependent precocious puberty (GDPP). Two gain-of-function mutations in KISS1 and GPR54 have... |
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- Type 2 diabetes mellitus and metabolic syndrome
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Jin Soon Hwang
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Clin Exp Pediatr. 2006;49(7):710-717. Published online July 15, 2006
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Type 2 diabetes mellitus in children and adolescents has been increasing for last 10 years. The increase in frequency of type 2 diabetes appears to parallel the increase in prevalence and severity of obesity in children and adolescents. The metabolic syndrome, cluster of potent risk factors for atherosclerotic cardiovascular disease and type 2 diabetes, consists of insulin resistance, obesity, hypertension... |
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- Original Article
- Review of Chromosomal Analyses Performed in a Single Hospital
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Hong Kug Kim, Nam Hyang Koo, Jin Soon Hwang, Sung Hwan Kim
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Clin Exp Pediatr. 2004;47(11):1157-1160. Published online November 15, 2004
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Purpose : Chromosomal aberration has an effect on the lives of both patients and families. Peripheral blood chromosomal analysis is useful to make a diagnosis and counsel the patient with chromosomal abnormality. We studied the cases with peripheral blood chromosomal analyses and investigated the positivity of peripheral blood chromosomal analysis.
Methods : We analyzed 650 patients with chromosomal analyses in Ajou... |
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- The Separate and Combined Effects of Insulin, Dexamethasone and
Growth Hormone on the OB Gene Expression and Leptin Secretion
from Cultured Human Visceral Adipose Tissue
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Il Tae Hwang, Kyung Hee Kim, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2003;46(8):795-802. Published online August 15, 2003
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Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue.
Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin+DEX(100 nM each), insulin+DEX+GH(100 nM insulin... |
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- Case Report
- A Case of Townes-Brocks Syndrome
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Hong Seop So, Hyun Ju Choi, Hye Sun Yoon, Jin Soon Hwang, Keun Chan Sohn
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Clin Exp Pediatr. 2003;46(4):382-384. Published online April 15, 2003
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Townes-Brocks syndrome is an uncommon autosomal dominant condition first described by Townes and Brocks in 1972. We experienced a newborn female who presented with clinical findings of Townes-Brocks syndrome in an otherwise unaffected family. The patient showed the full spectrum of anomalies including anterior placed anus, triphalangeal thumb, preaxial polydactyly, pre-auricular tags, microtia without opening, sensorineural hearing loss and unilateral... |
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- Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus
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Jin Soon Hwang, Sei Won Yang
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Clin Exp Pediatr. 2000;43(8):1106-1110. Published online August 15, 2000
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Purpose : Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic β-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic β-cell function. The aim of this study was to determine factors influencing the onset of honeymoon period in children with type... |
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- Re-Evaluation of Neonatal Screening Tests for Inborn Errors of
Metabolism with Dried Filter Paper Blood Spots
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Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
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Clin Exp Pediatr. 1999;42(12):1639-1644. Published online December 15, 1999
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Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates.
Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases... |
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- A Case of Successful Treatment of Pulmonary Alveolar Hemorrhage with Plasmapheresis in Child with Systemic Lupus Erythematosus
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Jae Hong Min, Kyung Hoon Paek, Kyung Mi Park, Jin Soon Hwang, Jung Sue Kim, Il Soo Ha, Hae Il Cheong, Kyou Seup Han, Yong Choi
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Clin Exp Pediatr. 1998;41(7):974-978. Published online July 15, 1998
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Seoul National University College of Medicine, Seoul, Korea
Pulmonary hemorrhage is a rare but possibly fatal complication of systemic lupus erythematosus(SLE). We report a case of massive pulmonary hemorrhage in a 14-year-old boy recently diagnosed as SLE. He developed massive pulmonary hemorrhage during the courses of i.v. methylprednisolone pulse therapy, and did not respond to i.v. cyclophosphamide. However, he rapidly... |
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